COMPOSITION FOR ENHANCING SENSITIVITY TO RADIOTHERAPY COMPRISING NOVEL FAK INHIBITOR

摘要

The present invention relates to a composition for enhancing sensitivity to radiotherapy, which comprises a novel compound inhibiting focal adhesion tyrosine kinase (FAK) protein as a target. More particularly, the present invention relates to a composition for enhancing radiotherapy and a pharmaceutical composition for preventing or treating cancer, which comprises a novel FAK inhibitor suppressing phosphorylation of FAK or Src and inhibiting activity thereof. The composition comprising a novel FAK inhibitor or a pharmaceutically acceptable salt thereof as an active ingredient according to the present invention reduces phosphorylation of FAK or Src to inhibit activity thereof, and induces destruction of cancer cells to treat cancer cells. Particularly, the composition is effective for enhancing sensitivity to radiotherapy and thus can be administered in combination with radiation exposure upon treatment of cancer to maximize the effect of radiotherapy.;COPYRIGHT KIPO 2017