The present invention is directed to compositions for preventing, ameliorating and / or treating vomiting or diarrhea, including noxious extracts. The compositions of the present invention exhibit a preventive, ameliorative, and / or therapeutic effect of vomiting or diarrhea due to vomiting or diarrhea suppressed by a 5-HT 3 receptor antagonist, especially a chemotherapeutic agent, an irradiation treatment, or anesthetic administration , Which selectively antagonize the 5-HT 3 receptor and do not act on dopamine receptors and do not cause side effects.
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