Method for making genome edited fowls by knocking out genes and genome edited fowls made by the same

摘要

The present invention relates to a method for preparing a recombinant adenovirus, which comprises introducing a nucleic acid encoding TALEN binding to a target gene into avian primitive germ cells to induce mutation in the target gene, injecting the mutant primitive avian germ cells into a receptor embryo; And a step of incubating and incubating eggs containing the receptor embryo to produce a genetic modification product. The method according to the present invention makes it possible to produce a new variety of algae in large quantities by targeting various genes very efficiently compared with the method based on conventional homologous recombination.