Skin external application composition and cosmetic composition comprising peptide derived silk cocoon or its derivatives with an anti-aging antioxidant or anti-inflammatory effect

摘要

The present invention relates to a topical composition and cosmetic composition containing a method of producing a peptide having an anti-aging, antioxidant, or anti-inflammatory efficacy of the cocoon-derived and the peptides, separated from the cocoon protein according to the present invention in more detail, and peptide having an amino acid sequence of Gly-Ser-Gly-Ala tablets lipid peroxidation due to UVB irradiation (lipid peroxide), inhibit the production of reactive oxygen species (reactive oxygen species, ROS), and around the skin cell defense mechanisms, such as the wnt It activates the inflammation-related factor in inhibiting the expression of iNOS and TNF-, and inhibit the expression of MMP-1 collagenase enzyme, and dermis total collagen content type I collagen (collagen-I), which accounts for 90% of the increase expression and, superoxide dismutase increases the expression of antioxidant enzymes such as (superoxide dismutase, SOD) aging caused by ultraviolet light, oxidation, and It may be useful to take advantage of the increase in the external preparation for skin and cosmetic to defend and improve.