A composition comprising extracts fractions or isolated active fractions of Magnoliae flos for prevention and treatment of chronic obstructive pulmonary disease

摘要

The present invention relates to a pharmaceutical composition for the prevention and treatment of chronic obstructive pulmonary disease, comprising as an active ingredient any one of a Magnoliae flos extract, a fraction obtained by fractionating the extract with an organic solvent, an active fraction, or a compound isolated therefrom , Wherein the extract of Shin, the fractions fractionated by using the organic solvent, the active fraction, or the compound isolated therefrom suppress the expression or promoter activity of TNF-α-induced MUC5AC in human lung cancer mucosal cells (H292) cells And it was confirmed that it can be used for the treatment of chronic obstructive pulmonary disease by inhibiting the number of inflammatory cells in the bronchoalveolar lavage fluid of the chronic obstructive pulmonary disease mouse model, inhibiting the production of active oxygen species, and decreasing the cytokine, , The fractions fractionated by using the organic solvent thereof, the active fractions, or the compounds isolated therefrom It may be useful as a pharmaceutical composition for preventing or treating chronic obstructive pulmonary disease.