The present invention relates to a mass production method of the recombinant EC-SOD protein using an expression optimized recombinant EC-SOD gene from the plant, and this, and more particularly containing the expressed optimization of recombinant EC-SOD gene in plants, and this recombinant expression vector, the recombinant transformed with an expression vector conversion plant cells, tissues, part of the plant or the whole, and method of producing transgenic plants using the above recombinant expression vectors and recombinant EC-SOD mass production method of protein, and the method as it is for the inflammatory diseases and blood composition for the prevention or treatment of disease caused by start-containing mass produced recombinant EC-SOD protein as an active ingredient. Or more As described, by the present invention by using a manufacturing method using the same and an expression optimized recombinant EC-SOD gene in plants expressing high EC-SOD protein, the enzymatic activity that is not modified on the crops, such as tobacco according to the low cost, It can be effectively used for mass production by developing effective and safe therapeutic proteins in various inflammatory diseases and diseases caused by angiogenesis with high efficiency.;
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