A bisphosphonates containing collagen based sustained delivery system for BMP and a method for manufacturing the same

摘要

The present invention provides a collagen-based BMP transporter that contains a bisphosphonate and optionally heparin to enhance the affinity of collagen and BMP in a collagen-based BMP transporter, thereby continuously releasing an appropriate concentration of BMP, And a collagen-based sustained-release BMP carrier capable of regulating the degree of release, and a method for producing the same. According to the present invention, it is possible to induce and promote bone differentiation of bone marrow-derived mesenchymal stem cells by continuously releasing BMP at a proper concentration, and to promote osteogenesis and bone regeneration in bone defect sites.;