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A bisphosphonates containing collagen based sustained delivery system for BMP and a method for manufacturing the same
A bisphosphonates containing collagen based sustained delivery system for BMP and a method for manufacturing the same
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机译:用于骨形态发生蛋白的含有胶原蛋白的双膦酸酯持续递送系统及其制造方法
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摘要
The present invention relates to a collagen-based BMP transporter which contains a bisphosphonate and optionally a heparin to enhance the affinity of collagen and BMP in a collagen-based BMP transporter, And a collagen-based sustained-release BMP carrier capable of controlling the degree of release, and a method for producing the same. According to the present invention, it is possible to induce and promote bone differentiation of bone marrow-derived mesenchymal stem cells by continuously releasing BMP at a proper concentration, and to promote bone formation and bone regeneration in the bone defect part.
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