Compositions for the prevention or treatment of metabolic syndrome or antioxidant containing extracts of black soybean leaves flavonol glycosides as an active ingredient

摘要

The present invention relates to an antioxidant composition for prevention or treatment of metabolic syndrome containing an extract of black bean curd and flavonol glycosides isolated therefrom as an active ingredient. The black bean leaf extract of the present invention and the extract Flavonol glycosides effectively inhibit? -Glucosidase activity, effectively inhibit LDL oxidation and DDP-4, exhibit excellent DPPH radical scavenging activity, excellent activity of inhibiting accumulation of reactive oxygen species (ROS) The present invention relates to a method for regulating the expression of major genes for diabetes, obesity, insulin resistance, fatty liver, hyperlipidemia and atherosclerosis, which is effective in promoting insulin secretion in cells, The ratio of plasma free fatty acid and plasma triglyceride is decreased, and plasma HDL-cholesterol Increases the concentration of the terol, decreases the arteriosclerosis index, increases erythrocyte catalase, SOD and GR activity, decreases the red blood cell lipid peroxide, TBARS, and decreases inflammatory cytokines, MCP-1 and PAI-1, By confirming that the concentration of the hormone lecithin is decreased and the plasma adiponectin concentration is increased, the black soybean leaf extract and the flavonol glycoside isolated therefrom are not only useful for preventing or treating metabolic syndrome, It can be usefully used as an antioxidant composition.