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ERYTHROFERRON AND ERFE-POLYPEPTIDES AND METHODS OF REGULATION OF IRON METABOLISM
ERYTHROFERRON AND ERFE-POLYPEPTIDES AND METHODS OF REGULATION OF IRON METABOLISM
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机译：赤铁铁和ERFE多肽以及铁代谢的调节方法
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摘要
1. An isolated purified synthetic and / or recombinant polypeptide which comprises a C-terminal sequence having about 95-100% identity sEFQLLLKGAVRQRERAEPEPCTCGPAGPVAASLAPVSATAGEDDDDVVGDVLALLAAPLAPGPRAPRVEAAFLCRLRRDALVERRALHELGVYYLPDAEGAFRRGPGLNLTSGQYRAPVAGFYALAATLHVALGEPPRRGPPRPRDHLRLLICIQSRCQRNASLEAIMGLESSSELFTISVNGVLYLQMGQWTSVFLDNASGCSLTVRSGSHFSAVLLGV sequence (SEQ ID NO: 16) .2. The polypeptide of claim 1 and further comprising an N-terminal sequence having approximately 70-100% sequence identity with MAPARRPAGARLLLVYAGLLAAAAAGLGSPEPGAPSRSRARREPPPGNELPRGPGESRAGPAARPPEPTAERAHSVDPPDAWMLFVRQSDKGVGPKKKK. An isolated purified synthetic and / or recombinant polypeptide which is from about 70 to 100% identity sMAPARRPAGARLLLVYAGLLAAAAAGLGSPEPGAPSRSRARREPPPGNELPRGPGESRAGPAARPPEPTAERAHSVDPRDAWMLFVRQSDKGVNGKKRSRGKAKKLKFGLPGPPGPPGPQGPPGPIIPPEALLKEFQLLLKGAVRQRERAEPEPCTCGPAGPVAASLAPVSATAGEDDDDVVGDVLALLAAPLAPGPRAPRVEAAFLCRLRRDALVERRALHELGVYYLPDAEGAFRRGPGLNLTSGQYRAPVAGFYALAATLHVALGEPPRRGPPRPRDHLRLLICIQSRCQRNASLEAIMGLESSSELFTISVNGVLYLQMGQWTSVFLDNASGCSLTVRSGSHFSAVLLGV sequence (SEQ ID NO: 1) iliMASTRRPVGARTLLACASLLAAMGLGVPESAEPVGTHARPQPPGAELPAPPANSPPEPTIAHAHSVDPRDAWMLFVKQSDKGINSKRRSKARRLKLGLPGPPGPPGPQGPPGPFIPSEVLLKEFQLLLKGAVRQRESHLEHCTRDLTTPASGSPSRVPAAQELDSQDPGALLALLAATLAQGPRAPRVEAAFHCRLRRDVQVDRRALHELGIYYLPEVEGAFHRGPGLNLTSGQYTAPVAGFYALAATLHVALTEQPRKGPTRPRDRLRLLICIQSLCQHNASLETVMGLENSSELFTISVNGVLYLQAGHYTSVFLDNASGSSLTVRSGSHFSAILLGL (SEQ ID NO: 2) .four. The polypeptide according to claim 3, where it contains essentially one of the following sequences: GLPGPPGPPGPQGPPGP (SEQ ID NO: 3), AHSVDPRDAWMLFV (SEQ ID NO: 4), AHSVDPRDAWMLFVXQSDKGXN (SEQ ID NO: 5), LLKRQLL : 6), GPRAPRVEAAF (SEQ ID NO: 7), VXRRALHELGXYYLPX (SEQ ID NO: 8), GLNLTSGQY (SEQ ID NO: 9), APVAGFYALAATLHVAL (SEQ ID NO: 10), XMGLEXSSELFTISVNGVLYLQL (11) (SEQ ID NO: 12), TSVFLDNASG (SEQ ID NO: 13), SLTVRSGSHFSA (SEQ ID NO: 14) and SLTVRSGSHFSAXLLGX (SEQ ID NO: 15), where X represents any amino acid. 5. An isolated purified synthetic and / or recombinant polypeptide that contains essentially GLPGPPGPPGPQGPPGP (SEQ ID NO: 3), AHSVDPRDAWMLFV (SEQ ID NO: 4), AHSVDPRDAWMLFVXQSDKGXN (SEQ ID NO: 5), LLQEFQLQEF , GPRAPRVEAAF (SEQ ID NO: 7), VXRRALHELGXYYLPX (SEQ ID NO: 8), GLNLTSGQY (SEQ ID NO: 9), APVAGFYALAATLHVAL (SEQ ID NO: 10), XMGLEXSSELFTISVNGVLYLQ (SEQ ID NO NO: 12), TSVFLDNASG (SEQ ID NO: 13), SLTVRSGSHFSA (SEQ ID NO: 14) and SLTVRSGSHFSAXLLGX (SEQ ID NO: 15), where X is any amino acid. 6. An isolated purified synthetic and / or recombinant polypeptide that contains essentially at least about 10, at least about 11, at least about 12, at least about 13, at least about 14, at least about 15 at least about 16, at least about 17, at least about 18, at least about 19, at least about 20, at least about 21, at least about 22, at least about 23, at least
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机译：1.一种分离的纯化合成的和/或重组的多肽，其包含具有约95-100％同一性sEFQLLLKGAVRQRERAEPEPCTCGPAGPVAASLAPVSATAGEDDDDVVGDVLALLAAPLAPGPRAPRVEAAFLCRLRRDALVERRALHELGVYYLPDAEGAFRRGPGLNLTSGQYRAPVAGFYALAATLHVALGEPPRRGPPRPRDHLRLLICIQSRCQRNASLEAIMGLESSSELFTISVNGVLYLQMGQWTSVFLDNASGCSLTVRSGSHFSAVLLGV序列（SEQ ID NO：16）的C-末端序列0.2。权利要求1的多肽，其进一步包含与MAPARRPAGARLLLVYAGLLAAAAAGLGSPEPGAPSRSRARREPPPGNELPRGPGESRAGPAARPPEPTAERAHSVDPPDAWMLFVRQSDKGVGPKKKK具有约70-100％序列同一性的N端序列。一种分离纯化合成的和/或重组的多肽，其是从约70至100％的同一性sMAPARRPAGARLLLVYAGLLAAAAAGLGSPEPGAPSRSRARREPPPGNELPRGPGESRAGPAARPPEPTAERAHSVDPRDAWMLFVRQSDKGVNGKKRSRGKAKKLKFGLPGPPGPPGPQGPPGPIIPPEALLKEFQLLLKGAVRQRERAEPEPCTCGPAGPVAASLAPVSATAGEDDDDVVGDVLALLAAPLAPGPRAPRVEAAFLCRLRRDALVERRALHELGVYYLPDAEGAFRRGPGLNLTSGQYRAPVAGFYALAATLHVALGEPPRRGPPRPRDHLRLLICIQSRCQRNASLEAIMGLESSSELFTISVNGVLYLQMGQWTSVFLDNASGCSLTVRSGSHFSAVLLGV序列（SEQ ID NO：1）iliMASTRRPVGARTLLACASLLAAMGLGVPESAEPVGTHARPQPPGAELPAPPANSPPEPTIAHAHSVDPRDAWMLFVKQSDKGINSKRRSKARRLKLGLPGPPGPPGPQGPPGPFIPSEVLLKEFQLLLKGAVRQRESHLEHCTRDLTTPASGSPSRVPAAQELDSQDPGALLALLAATLAQGPRAPRVEAAFHCRLRRDVQVDRRALHELGIYYLPEVEGAFHRGPGLNLTSGQYTAPVAGFYALAATLHVALTEQPRKGPTRPRDRLRLLICIQSLCQHNASLETVMGLENSSELFTISVNGVLYLQAGHYTSVFLDNASGSSLTVRSGSHFSAILLGL（SEQ ID NO：2）。四。 4.根据权利要求3所述的多肽，其中其基本上包含以下序列之一：GLPGPPGPPGPQGPPGP（SEQ ID NO：3），AHSSVDPRDAWMLFV（SEQ ID NO：4），AHSSVDPRDAWMLFVXQSDKGXN（SEQ ID NO：5），LLKRQLL：6），GPRAPRVEAAF （SEQ ID NO：7），VXRRALHELGXYYLPX（SEQ ID NO：8），GLNLTSGQY（SEQ ID NO：9），APVAGFYALAATLHVAL（SEQ ID NO：10），XMGLEXSSELFTISVNGVLYLQL（11）（SEQ ID NO：12），TSVFLDNASG（SEQ （ID NO：13），SLTVRSGSHFSA（SEQ ID NO：14）和SLTVRSGSHFSAXLLGX（SEQ ID NO：15），其中X代表任何氨基酸。 5.一种分离的纯化的合成和/或重组多肽，其基本上包含GLPGPPGPPGPQGPPGP（SEQ ID NO：3），AHSSVDPRDAWMLFV（SEQ ID NO：4），AHSSVDPRDAWMLFVXQSDKGXN（SEQ ID NO：5），LLQEFQLQEF，GPRAPRVEAAF（SEQ ID NO：7）。 ），VXRRALHELGXYYLPX（SEQ ID NO：8），GLNLTSGQY（SEQ ID NO：9），APVAGFYALAATLHVAL（SEQ ID NO：10），XMGLEXSSELFTISVNGVLYLQ（SEQ ID NO：12），TSVFLDNASG（SEQ ID NO：13），SLTVRSGSHFSA（SEQ ID NO：10） SEQ ID NO：14）和SLTVRSGSHFSAXLLGX（SEQ ID NO：15），其中X是任何氨基酸。 6.一种分离的纯化的合成和/或重组多肽，其基本上包含至少约10，至少约11，至少约12，至少约13，至少约14，至少约15，至少约16，至少大约17，至少大约18，至少大约19，至少大约20，至少大约21，至少大约22，至少大约23，至少
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