Method for monitoring the effectiveness of antitumor therapy of non-small cell lung cancer

摘要

The invention relates to medicine, namely to oncology, and concerns methods of monitoring efficiency of anticancer treatment of non-small cell lung cancer. A method involves determining expression levels of microRNA markers in patient's peripheral blood after surgical management, wherein levels of microRNA-19b, microRNA-125b and combination of microRNA-125b/microRNA-19b are determined in 2 weeks, 3 and 6 months, 1 and 2 years after the treatment, and when obtaining linear model of microRNA expression levels changing dynamics, characterized by gradual increase of microRNA-19b, reduction of microRNA-125b and combination of microRNA-125b/microRNA-19b relative to initial values, disease progression is determined, and when obtaining quadratic model of microRNA expression levels changing dynamics, characterized by alternation of increasing or decreasing of expression levels of analyzed microRNA decreased or increased analogous values relative to initial values, remission is determined. New technical result is more accurate early diagnosis of progression of non-small cell lung cancer due to regular comparative analysis of end sections of microRNA expression during dynamic observation.