DIFFERENTIAL DIAGNOSTIC TECHNIQUE FOR PRIMARY AND SECONDARY IMMUNE RESPONSE TO MEASLES VIRUS

摘要

FIELD: medicine.;SUBSTANCE: invention relates to medicine, namely to immunology and can be used for differential diagnosis of primary and secondary immune response to measles virus. It is ensured by separation of types of immune response into primary and secondary by limit criteria, based on calculated using ROC analysis for IgG1 and IgG3 subclasses. Determination of amount of specific measles antibodies, relating to subclasses IgG1 and IgG3, is carried out using ELISA analysis. If limit values for IgG145.42 % and for IgG342 % are obtained of total amount of measles IgG antibodies primary immune response is diagnosed. If limit values for IgG145.42 % and for IgG342 % are obtained of total amount of measles IgG antibodies primary immune response is diagnosed.;EFFECT: use of given method enables control of measles immunity quality and diagnosis of cases of primary and secondary vaccinal failures.;1 cl, 3 tbl, 2 dwg