QUINOLINE AND QUINOXALINE DERIVATIVES EFFECTIVE AS CYSTEINYL-LEUKOTRIENE ANTAGONISTS

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to organic chemistry, specifically to a heterocyclic compound of formula (IA) or to a pharmaceutically acceptable salt thereof, where in each case R₁ and R₃ are independently selected from a group comprising hydrogen, halogen, -OH, -C_1-2alkyl, -O-C_1-2alkyl, -O-C₁halogenalkoxy, -N(C₁alkyl)₂; R₂ represents hydrogen; W represents a group selected from -CH= or -N=; X represents a group selected from -CH=CH- or -N=CH-, where nitrogen from -N=CH- is directly bonded with ring 'a'; Y represents a group selected from -CH=CH- or -C≡C-; Z denotes a bond or group selected from -(CH₂)_n- and -CH=CH-; A is a group selected from -OR, -O(CH₂)_nphenyl, -O(CH₂)_nthiophene; P is selected from a group comprising -O-; Q is a group selected from -COOH; where R is selected from a group comprising hydrogen, -C_1-6alkyl, -C_3-6cycloalkyl, -C₁alkyl (C_3-6cycloalkyl), -C_3-6alkenyl and -C_3-6alkynyl; 'n' in each case represents an integer, selected from 1, 2 or 3; 'm' in each case represents an integer, selected from 0-3, inclusive. Invention also relates to a compound of formula (Id), where radicals are described in patent claim.;EFFECT: obtaining novel heterocyclic compounds effective as antagonists of cysteinyl-leukotriene.;9 cl, 1 dwg, 2 tbl, 67 ex;