RECTAL SUPPOSITORIES WITH ANALGESIC ACTION

摘要

FIELD: medicine.;SUBSTANCE: invention relates to medicine, in particular to drugs, and can be used for production of rectal suppositories for relieving of pain of various origin: postoperative pain, vertebrogenic radicular pain, arthritis, cancer pain, cardialgia, headache, dysmenorrhea, kidney and liver colics. Rectal suppositories proposed by authors have analgesic action and contain preparation of non-steroidal row and base, differing by fact, that preparation of non-steroidal row contains ketorolac and additionally contains amitriptyline, while base contains silicon glicerolates in 3-molar excess of glycerine composition Si(C₃H₇O₃)₄⋅3C₃H₈O₃ and polyethylene glycol PEG-4000 with following ratio of components, calculated in g per one suppository: ketorolac 0.021÷0.031, amitriptyline 0.003÷0.008, PEG-4000 1.793÷1.804, silicon glicerolates 0.768÷0.773.;EFFECT: production of rectal suppositories.;1 cl, 2 tbl, 2 ex