METHOD OF PREDICTING HIGH RISK OF REPRODUCTIVE LOSS IN FIRST TRIMESTER OF PREGNANCY

摘要

FIELD: medicine.;SUBSTANCE: invention relates to field of medicine, in particular to obstetrics and gynecology, and is intended for prediction of high risk of reproductive loss in first trimester of pregnancy. From peripheral venous blood of women DNA is extracted with the following amplification of polymorphous variants of A66G of gene MTRR, -31C-T (rs1143627) IL-1β, -174G-C (rs1800795) IL-6 and C677T (rs1801133) MTHFR. In case of detection of one of four genotypes: -31CT IL-1β / -174GG IL-6 / 677CT MTHFR / 66GG MTRR; -31CT IL-1β / -174CC IL-6 / 677CC MTHFR / 66AG MTRR; -31CC IL-1β / -174CC IL-6 / 677CC MTHFR/ 66AG MTRR; -31CC IL-1β / -174GC IL-6 / 677CT MTHFR/ 66AG MTRR, high risk of reproductive loss is predicted in first trimester of pregnancy.;EFFECT: invention makes it possible to form among women groups of risk of reproductive loss in first trimester of pregnancy and timely realise necessary thethapeutic-preventive measures in these groups.;1 dwg, 1 tbl, 7 ex