PEPTIDE-IMMUNOGEN USED IN THERAPEUTIC VACCINE FOR TREATMENT OF METASTATIC BREAST CANCER OF CATS AND DOGS

摘要

FIELD: medicine, veterinary medicine.;SUBSTANCE: peptide immunogen with the following amino acid sequence is used: CKGPIVLDGVIKTQPHAAEK (SEQ ID NO: 1), identical to the amino acid sequence of the active center of EGFR receptor of cats and dogs. To enhance the immune response, the peptide comprises covalently linked carrier protein. It contains bovine serum albumin (BSA) or cationized bovine serum albumin, or ovalbumin or hemocyanin as a carrier protein.;EFFECT: application of the peptide allows to form endogenous antibodies of narrow specificity in animal bodies, that are directed specifically to functionally significant areas of the tumour cells receptor, and to block the main paths of tumour growth and metastasis due to the high peptide immunogenicity and ensured formation of immune response to the protective epitopes of targeted tumour markers only.;2 cl, 1 tbl, 1 dwg