PEPTIDE-IMMUNOGEN USED IN THERAPEUTIC VACCINE FOR METASTATIC BREAST CANCER TREATMENT

摘要

FIELD: medicine.;SUBSTANCE: peptide immunogen is characterized by the amino acid sequence CKGPIVLDGVIKTQPHAAEK (SEQ ID NO: 1), identical to the amino acid sequences of the active site of the EGFR receptor, and contains a covalently bound carrier protein. It contains bovine serum albumin (BSA), or cationized bovine serum albumin, or ovalbumin or hemocyanin as the carrier protein.;EFFECT: application of this invention allows preparation of an immunogen peptide used in a therapeutic vaccine for metastatic breast cancer treatment due to the high immunogenicity of the peptide, and for assurance of an immune response only to the protective epitopes of the target tumour markers that block the main pathways of tumour growth and metastasis.;2 cl, 1 dwg, 1 tbl