METHOD OF PRODUCING NON-RACEMIC 1- (ADAMANT-1-YL) -2- (2-NITRO-1-PLENYLETHYL) BUTANE-1,3-DIONE

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to method of producing non-racemic 1- (adamant-1-yl) -2- (2-nitro-1-phenylethyl) butane-1,3-dione of formula I . The method is carried out by enantioselective joining of 1- (adamant-1-yl) butan-1,3-dione to ω-nitrostyrene in the presence of a nickel complex of formula II in accordance with the following scheme (R = H). The method is characterized by the fact that 1,3-diketone containing adamantyl substituent is used as the Michael donor.;EFFECT: invention enables to simplify the process, reduce its price and obtain the product with good output.;2 ex