LIDOCAIN RECEPTION DIAGRAM FOR APPLICATION IN LONG-TERM TREATMENT OF PAIN IN BLADDER AND IRRITATION DURING URINATION

摘要

FIELD: medicine.;SUBSTANCE: method for treatment of bladder pain and/or urinary irritation symptoms comprises continuous administration of lidocaine to the patient's bladder during a treatment period of 24 hours or longer in an average therapeutically effective amount of about 10 mg to about 30 mg of lidocaine, based on the free base (FBE, free base equivalent) to achieve a therapeutic effect that persists after the end of the treatment period. A method for treatment of bladder pain and/or urinary irritation symptoms is also proposed, comprising continuous administration of an anesthetic or analgesic agent to the patient's bladder during a treatment period of 24 hours or longer in an amount effective to achieve a therapeutic effect that persists after the end of the treatment period. A method for treatment of bladder pain and/or urinary irritation symptoms is also proposed, comprising continuous administration of an anesthetic or analgesic agent to the patient's bladder during a treatment period of at least 24 hours in an amount effective to achieve a measurable plasma concentration, continuously throughout the treatment period. A device for drug delivery is also proposed to be used for treatment of bladder pain and/or urinary irritation symptoms, comprising an elastic device housing defining the lumen of a reservoir for a drug containing a useful load of lidocaine. The device body is designed to continuously control the release of lidocaine into the patient's bladder over a treatment period of at least 24 hours, with an average amount of about 5 mg to about 30 mg of lidocaine (FBE) per day during the treatment period.;EFFECT: inventions provide effective treatment of bladder pain and/or urinary irritation symptoms, while reducing side effects of therapy to provide a lasting therapeutic effect that persists for at least 14 days after the active treatment period due to the proposed intravesical administration regimen.;23 cl, 56 dwg, 6 tbl, 3 ex