METHOD FOR PREDICTION OF ANTIPLATELET THERAPY EFFICIENCY REDUCTION RISK

摘要

FIELD: medicine.;SUBSTANCE: invention is designed to predict the risk of decrease in the efficiency of antiplatelet therapy with clopidogrel and acetylsalicylic acid preparations (ACA) in patients with ischemic heart disease (IHD) who underwent coronary arteries stenting. DNA is isolated from the venous blood of patients. Polymorphic variants T-786C of the NOS3 gene are determined by allele-specific PCR. Detection of PCR products is performed by electrophoresis method. An increased risk of a decrease in the efficiency of antiplatelet therapy with clopidogrel and acetylsalicylic acid preparations is predicted in carriers of the -786CC genotype of NOS3 gene.;EFFECT: invention allows to assess the risk of developing resistance to antiplatelet drugs and to timely adjust the therapy and improve the quality of treatment.;2 tbl, 3 ex