METHOD FOR EXAMINING CHILDREN WITH SUSPECTED ALAGILLE SYNDROME

摘要

FIELD: medicine.;SUBSTANCE: for children of the first 3-5 months of life, in the presence of a symptomatic complex which consists in low birth weight, long icteritous period which lasts more than 2 weeks, and for children older than 5 months with the presence of pruritus, hepatitis/hepatosplenomegaly, acholia/hypochole stool, a biochemical blood test is performed to confirm the signs of cholestasis, such as direct hyperbilirubinemia, moderate cytolytic activity, increased cholesterol level, after which, if signs of cholestasis are detected, ultrasound examination of the abdominal organs cavity is performed, and if heterogeneity of hepatic parenchyma, and thickening of the walls of the intrahepatic bile ducts is detected, cardiac ultrasound and radiography of thoracolumbar spine are performed, and if the changes concerning cardiovascular system, skeletal systema and nephros are detected, DNA testing for verifying Alagille syndrome is conducted.;EFFECT: diagnostic efficiency.;5 dwg, 1 ex