METHOD FOR PREDICTION OF DEVELOPMENT OF ABNORMAL UTERINE BLEEDING IN PUBERTY PERIOD FOR ADOLESCENT GIRLS BORN WITH DELAYED PRENATAL GROWTH

摘要

FIELD: medicine.;SUBSTANCE: prediction method includes determination of the sexual development rates of the girl, in particular the body mass index and the age of menarche, determination of the TT homozygote in the NOS3 (-786) TC gene, determination of the CC homozygote in the ESR1 (-397) TC gene and calculation of the prognostic Index. If the prognostic index is greater than 0, a conclusion is made about the low risk of abnormal uterine bleeding in the puberty period; if the prognostic index is less than or equal to 0, a high risk of formation of abnormal uterine bleeding in the puberty period is predicted.;EFFECT: invention provides timely diagnostics, allows to increase the effectiveness of treatment and avoid serious complications and relapses of abnormal uterine bleeding of the puberty period.;1 tbl, 3 ex