IMMUNOTHERAPY OF NON-SMALL LUNG CANCER USING GENETICALLY ENGINEERED GD2-SPECIFIC T CELLS

摘要

The present invention concerns immunotherapy for brain cancers having cells that comprise the ganglioside GD2 antigen. In specific embodiment, T cells having a chimeric receptor that targets GD2 is employed, the chimeric receptor comprises antibody, cytoplasmic signaling domain from the T cell receptor, and costimulatory molecule(s).