首页>
外国专利>
METHODS FOR PREPARING HIGH THROUGHPUT PEPTIDOMIMETICS, ORALLY BIOAVAILABLE DRUGS AND COMPOSITIONS CONTAINING SAME
METHODS FOR PREPARING HIGH THROUGHPUT PEPTIDOMIMETICS, ORALLY BIOAVAILABLE DRUGS AND COMPOSITIONS CONTAINING SAME
展开▼
机译:制备高通透性肽假药,口服可生物利用的药物和包含相同成分的组合物的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Provided herein are methods to generate and screen peptides that exhibit drug like stabilities in vitro and in vivo. By selecting for enzyme resistance, Applicants are able to derive peptides that are not only stable to a broad spectrum of proteases, but also stable to other drug processing enzymes such as cytochrome P450s. This approach provides a general method to the rapid development of highly stable peptides for therapeutic development and diagnosis. The peptides are further modified for oral bioavailability. The methods can be applied to similar peptides for the making of therapeutic compositions.
展开▼