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SIGNIFICANCE OF INTRATUMORAL HER2 HETEROGENEITY IN BREAST CANCER AND USES THEREFOR
SIGNIFICANCE OF INTRATUMORAL HER2 HETEROGENEITY IN BREAST CANCER AND USES THEREFOR
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机译:管内HER2异质性在乳腺癌中的意义及应用
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摘要
Disclosed herein are methods for predicting the response to a HER2-directed therapy and for scoring a breast cancer tumor sample. In some embodiments, the methods include contacting the sample with an antibody that specifically binds HER2 protein and detecting presence and/or amount of HER2 protein and contacting the sample with a nucleic acid probe that specifically binds to HER2 genomic DNA and detecting presence and/or amount of HER2 genomic DNA (such as HER2 gene copy number). In some embodiments, the methods further include detection of a centromere nucleic acid (such as chromosome 17 centromere DNA) and contacting the sample with an antibody that specifically binds ER protein and detecting presence and/or amount of ER protein in the same sample.
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