REPROGRAMMING BONE ENDOTHELIAL CELLS FOR USE IN BONE ANGIOGENESIS AND OSTEOGENESIS

摘要

The present invention relates to a factor for reprogramming bone endothelial cells to promote bone angiogenesis and osteogenesis as well as to an ex vivo method for reprogramming a bone endothelial cell to achieve cells able to mediate bone angiogenesis and osteogenesis. The subtype of bone endothelial cells mediating bone angiogenesis and osteogenesis express CD31 and Endomucin as markers.