首页>
外国专利>
TRANSCATHETER VALVE PROSTHESES HAVING A SEALING COMPONENT FORMED FROM TISSUE HAVING AN ALTERED EXTRACELLULAR MATRIX
TRANSCATHETER VALVE PROSTHESES HAVING A SEALING COMPONENT FORMED FROM TISSUE HAVING AN ALTERED EXTRACELLULAR MATRIX
展开▼
机译:导管瓣膜假体具有由组织制成的密封组件,具有改变的细胞外基质
展开▼
页面导航
摘要
著录项
相似文献
摘要
A transcatheter valve prosthesis including a sealing component formed from a tissue having an altered extracellular matrix. The altered extracellular matrix includes at least one weakened connection such that the tissue is configured to swell or expand upon contact with a fluid. The altered extracellular matrix does not reduce compressibility of the tissue such that the delivery profile of the transcatheter valve prosthesis is not adversely affected. The tissue having an altered extracellular matrix transforms from a compressed state for delivery within a vasculature to an expanded state in situ when blood infiltrates or flows within the at least one weakened connection. The sealing component in the expanded state conforms to the geometry of the native valve tissue, thereby preventing paravalvular leakage at the implantation site.
展开▼