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SOLUBLE UNIVERSAL ADCC-ENHANCING SYNTHETIC FUSION GENE AND PEPTIDE TECHNOLOGY AND ITS USE THEREOF
SOLUBLE UNIVERSAL ADCC-ENHANCING SYNTHETIC FUSION GENE AND PEPTIDE TECHNOLOGY AND ITS USE THEREOF
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机译:可溶性通用ADCc增强合成融合基因和多肽技术及其应用
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摘要
Novel synthetic biology-based ADCC technologies are provided that enhance or enable ADCC responses, for example, through a rationally-designed soluble universal ADCC enhancer protein (SUAEP) where a high-affinity CD3-binding domain is fused to a high-affinity Fc-binding domain. The SUAEP technology can be used to prevent or treat cancers, infectious, inflammatory or autoimmune diseases, and other diseases where elimination of diseased cells is desirable.
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