LOSSLESS CRYO-GRID PREPARATION STAGE FOR HIGH-RESOLUTION ELECTRON MICROSCOPY

摘要

The invention relates to a preparation system for preparing a sample for electron microscopy, comprising:—a liquid handling system (0) comprising a dispensing head (1), wherein said liquid handling system (0) is configured to aspirate and dispense a volume of a sample via the dispensing head (1),—a support structure (2) that is configured to accommodate the sample, a temperature-controlled stage (4) that is configured to keep said support structure (2) at a pre-defined temperature when the support structure (2) is arranged on the temperature-controlled stage (4), a first adapter (3) configured to hold said support structure (2), a transfer mechanism (60) that is configured to be connected to the first adapter (3) holding the support structure (2) and to move said support structure (2) into a container (8) containing a liquid cryogen (80) so that the sample on the support structure (2) contacts the cryogen (80). Furthermore, the invention relates to a corresponding method.