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COORDINATED-CONTROL COENZYME Q10 FERMENTATION PRODUCTION PROCESS BASED ON ONLINE OXYGEN CONSUMPTION RATE AND ELECTRICAL CONDUCTIVITY
COORDINATED-CONTROL COENZYME Q10 FERMENTATION PRODUCTION PROCESS BASED ON ONLINE OXYGEN CONSUMPTION RATE AND ELECTRICAL CONDUCTIVITY
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机译:基于在线耗氧率和电导率的协调控制辅酶Q10发酵生产工艺
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摘要
The present invention relates to an optimized fermentation process of coenzyme Q10, particularly to a fermentation process of coenzyme Q10 via flow feeding based on cooperative control of changes of online oxygen consumption rate and conductivity. During the fermentation process of coenzyme Q10 production strains, the oxygen consumption rate is controlled between 30-150 mmol/L·h and the conductivity is maintained between 3.0-30.0ms/cm via flow feeding, so as to facilitate strain growth and the start of coenzyme Q10 synthesis and accumulation. The present invention can substantially increase output of coenzyme Q10 and greatly reduce the production cost with simple process control and strong operability, thus being applicable to large-scale industrial production.
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