Disclosed is a fed-batch coordinated-control coenzyme Q10 fermentation production process based on changes in the online oxygen consumption rate and in the online electrical conductivity. In the fermentation process of coenzyme Q10 production strains, the oxygen consumption rate is controlled to be 30-150mmol/L·h the electrical conductivity is maintained at 3.0-30.0ms/cm through fed-batch processing, so as to promote thallus growth and the start and accumulation of coenzyme Q10 synthesis. The method can greatly increase the output of coenzyme Q10 and considerably reduce production cost. The method has the advantages of simple process control and high operability, and is suitable for large-scale industrial production.
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