METHOD OF DEVELOPING SMALL MOLECULE PEPTIDE CONJUGATES FOR BIOMEDICAL APPLICATIONS

摘要

This application provides a platform design wherein a substrate peptide of the protein-protein interaction complex is tagged with a variety of small molecule fragments using amide chemistry. The method of hit discovery coupled with subsequent amide-mediated rapid diversification for lead generation reduces time and cost to discovery and development of target specific small molecule leads for the inhibition of protein-protein interactions.