PROCESS FOR THE PREPARATION OF AN INTERMEDIATE FOR THE SYNTHESIS OF I.A. CARFILZOMIB

摘要

The present invention provides a compound which is the trichloroacetic acid salt of a compound of Formula (II) wherein R is selected from the group consisting of H, CH₃-, (CH₃)₂CH-, (CH₃)₂CHCH₂-, CH₃CH₂CH(CH₃)-, and PhCH₂-, and a process for its preparation.;Also provided is a process for its preparation based on the stereoselective epoxidation of the corresponding olefin precursor and a process for the preparation of several pharmaceutically active ingredients comprising the preparation of the compound of formula (II).