METHYLENE BLUE COMPLEX USED FOR SKIN DISEASE, AND APPLICATIONS THEREOF

摘要

PROBLEM TO BE SOLVED: To provide: complex particles using methylene blue for treating a skin disease caused by propionibacterium acnes or staphylococcus aureus; and a composition for treatment including the complex particles.SOLUTION: The complex particles are used as a photosensitizer for a photodynamic therapy and are complex particles having a micelle form in which hydrophilic methylene blue and two hydrophobic organic acids are combined, so that pore penetration is easy and a time can be significantly reduced to 30 minutes or less compared with existing phototherapy requiring a waiting time of 1 to 3 hours. Further, in order to minimize side effects of a residual photosensitizer in phototherapy using an existing photosensitizer due to photoreaction and photobleaching of the methylene blue-organic acid complex, a light protection (light blocking or light shielding) time when contact of light needs to be avoided for 24 hours or more after treatment can be significantly reduced to 3 hours or less, and target treatment for propionibacterium acnes, staphylococcus aureus or the like which causes acne is enabled.SELECTED DRAWING: Figure 1