TYPE 2 RICKETS MODEL ANIMAL HAVING VARIANT TYPE VITAMIN RECEPTOR GENE, AND PRODUCTION METHOD THEREOF

摘要

PROBLEM TO BE SOLVED: To provide an evaluation system capable of evaluating accurately a physiological effect of a compound itself even to not only a vitamin D derivative having 1α-position hydroxy group but also a vitamin D derivative not having 1α-position hydroxy group.;SOLUTION: There is provided a gene-modified non-human animal manifesting a variant type vitamin D receptor, and showing a symptom of type 2 rickets. Variation of the variant type vitamin D receptor is variation to an arginine residue equivalent to the 270-th of the vitamin D receptors of a rat.;SELECTED DRAWING: None;COPYRIGHT: (C)2018,JPO&INPIT