VARIANT TYPE ASXL1 KNOCK-IN MOUSE

摘要

PROBLEM TO BE SOLVED: To provide a variant type ASXL1 knock-in mouse capable of becoming a model mouse in a precancerous state of a myeloid tumor.;SOLUTION: In a knock-in mouse, a variant type ASXL1 gene of a mouse, which imitates an ASXL1 mutant gene observed in a human myelodysplastic syndrome (MDS) patient, is knocked in, and the gene is specifically developed in hematopoietic cells.;SELECTED DRAWING: None;COPYRIGHT: (C)2019,JPO&INPIT