Compositions and methods for linking type I and type II extracellular domains as heterologous chimeric proteins

摘要

The present invention relates to compositions and methods comprising chimeric proteins used for the treatment of diseases, such as immunotherapy against cancer and autoimmunity, among others. In part, the present invention provides, in various embodiments, fusions of extracellular domains of transmembrane proteins that can have stimulatory or inhibitory effects. The present invention, in various aspects, provides compositions and methods that are useful in cancer immunotherapy, such as manipulating or modifying an immune signal to provide a therapeutic benefit. [Selection] Figure 3