Composition comprising tumor suppressor gene therapy and immune checkpoint therapy for the treatment of cancer

摘要

Provided herein are methods and compositions for treating cancer in an individual, the method comprising providing the individual with an effective amount of at least one immune checkpoint inhibitor, and p53 and / or MDA-7 ( IL24) administering gene therapy. Provided herein are methods for enhancing anti-tumor efficacy by administering extracellular matrix degrading proteins. Also provided herein are methods for enhancing anti-tumor efficacy by administering metronomic chemotherapy (for the drugs described above, 5FU + CTX + GM-CSF) in combination with p53 and / or IL24 gene therapy. Provided.