Masking chimeric antigen receptor T cells for tumor specific activation

摘要

The invention includes (a) a masking peptide; (b) one or more antigen-specific targeting domains; (c) an extracellular spacer domain; (d) a transmembrane domain; (e) at least one costimulatory domain; (F) A masked chimeric antigen receptor comprising an intracellular signaling domain. mCAR is activated upon cleavage of the masking peptide.