Novel immunoglobulin binding proteins and their use in affinity purification

摘要

The present disclosure relates to a non-natural binding protein comprising one or more non-natural immunoglobulin (Ig) binding domains, wherein at least one non-natural Ig binding domain comprises the amino acid sequence X1X2X3XiXsX5X7XsQQX11AFYX1sX15LX1sX19PX21LX23X24X2X2X3X4X4 The present disclosure also relates to compositions such as affinity matrices comprising the non-natural Ig binding proteins of the present invention. The use of these Ig binding proteins or compositions for affinity purification of immunoglobulins and methods of affinity purification. [Selection] Figure 8