Anti-transferrin receptor antibody with affinity tailored to purpose

摘要

Herein, anti-transferrin receptor antibodies that specifically bind to human and cynomolgus transferrin receptors are reported. The antibody comprises i) a humanized heavy chain variable domain obtained from the heavy chain variable domain of SEQ ID NO: 01, and ii) a humanized light chain variable domain obtained from the heavy chain variable domain of SEQ ID NO: 26. Including. Here, the antibody has an off-rate for human transferrin receptor that is less than (ie, at most) that of anti-transferrin receptor antibody 128.1 for cynomolgus monkey transferrin receptor. Here, the off-rate is measured by surface plasmon resonance, wherein anti-transferrin receptor antibody 128.1 has a heavy chain variable domain of SEQ ID NO: 64 and a light chain variable domain of SEQ ID NO: 65.