PREDICTION OF PROGRESSION TO ADVANCED AGE-RELATED MACULAR DEGENERATION USING POLYGENIC SCORE

摘要

PROBLEM TO BE SOLVED: To provide prediction of progression to advanced age-related macular degeneration (AMD) using a polygenic score.SOLUTION: The invention provides a method for identifying an individual suffering from intermediate age-related macular degeneration (AMD) with a higher risk of progression to advanced AMD by using a polygenic score calculated based on the results of genome-wide gene association studies using thousands of single nucleotide polymorphisms (SNPs), the method comprising: (a) determining in a biological sample from a subject the presence or absence of risk alleles of common allelic variants associated with AMD at a plurality of independent loci; and (b) calculating the polygenic score for the subject.SELECTED DRAWING: None