Substituted pyrazole and pyrrole compounds and methods of using them to inhibit translation initiation and to treat diseases and disorders related thereto

摘要

Disclosed are pyrazole compounds, and pharmaceutical compositions, and methods of using the same. One embodiment is a compound having the structure (I): And pharmaceutically acceptable salts and N-oxides thereof, wherein X ¹ , X ² , Z ¹ , Z ² , a ring system represented by “a”, R ¹ , A ^1A , L ^1B , A ^1B , L ^1A , L ² , Q, L ³ , R ³ , A ^4A , L ^4B , A ^4B , L ^4A , R ⁴ , L ⁵ and R ⁵ are as described herein. In certain embodiments, the compounds disclosed herein can be used to interfere with the elF4E / eiF4G interaction to treat hyperproliferative disorders, neurological diseases or disorders or autism.