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PHARMACEUTICAL COMPOSITION FOR TREATMENT OF MYOCYPATIA COMPRISING A Glucagon-like Peptide-1 Receptor Promoter

机译:包含胰高血糖素样肽-1受体启动子的肌萎缩症的药物组合物

摘要

The present invention relates to glucagon-like peptide-1 (GLP-1), GLP-1 fragment, GLP-1 secretion increase promoter, GLP-1 degradation inhibitor, GLP-1 receptor (GLP-1R) enhancer, or exendin The present invention relates to a pharmaceutical composition for preventing or treating muscular atrophy or muscular atrophy comprising -4, and a method for treating muscular atrophy or myopathy using the pharmaceutical composition. When the pharmaceutical composition for preventing or treating muscular atrophy or sarcopenia provided by the present invention is administered to an individual who has developed muscular atrophy or sarcopenia, the weight decreased due to muscular atrophy or sarcopenia, Since the expression level of genes involved in skeletal muscle weight, grip strength and muscle generation can be restored to a normal state, it will be widely used in the development of effective therapeutic agents for muscle atrophy or myopathy. [Selection] FIG.
机译:本发明涉及胰高血糖素样肽-1(GLP-1),GLP-1片段,GLP-1分泌增加启动子,GLP-1降解抑制剂,GLP-1受体(GLP-1R)增强子或exendin。本发明涉及用于预防或治疗肌肉萎缩或肌肉萎缩的药物组合物,该药物组合物包括-4,以及使用该药物组合物治疗肌肉萎缩或肌病的方法。当将本发明提供的用于预防或治疗肌肉萎缩或肌肉减少症的药物组合物施用于已发展为肌肉萎缩或肌肉减少症的个体时,由于肌肉萎缩或肌肉减少症而使体重降低,因为涉及骨骼肌的基因的表达水平体重,握力和肌肉生成可以恢复到正常状态,它将被广泛用于开发肌肉萎缩或肌病的有效治疗剂。 [选择]

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