HUMAN BONE-FORMING CELLS IN TREATMENT OF CONDITIONS AND BONE DISEASES ASSOCIATED WITH IMMUNODEFICIENCY OR IMMUNOSUPPRESSION

摘要

PROBLEM TO BE SOLVED: To provide a method for therapeutic application of bone-forming cells in the treatment of conditions and bone diseases associated with immunodeficiency or immunosuppression.SOLUTION: According to the present invention, there is provided a therapeutic pharmaceutical composition for treating conditions and bone diseases associated with immunodeficiency or immunosuppression, the composition comprising isolated bone-forming cells exhibiting antigen-presenting cell properties and having expression of HLA-II. Here, the conditions and bone diseases associated with immunodeficiency or immunosuppression include osteoporosis, osteopenia, bone fragility, bone necrosis, bone fracture, microfracture, or osteolysis. In addition, 52.8% to 88.4% of isolated osteogenic cells express HLA-II. The isolated osteogenic cells have expression of alkaline phosphatase (ALP), one or more of type 1 procollagen amino terminal propeptide, osteonectin, bone sialoprotein, etc., and calcify the external environment, as well as express HLA-I.SELECTED DRAWING: None