Method for preparing sixth crystalline form of sofosbuvir

摘要

The present invention relates to a process for preparing the sixth crystalline form of sofosbuvir. The method is simple to operate, the process conditions are stable, the reproducibility is good, the yield is high and the purity is high, and no viscous gel-like product is formed during the process. The problem of clogging the discharge port is solved. This method is suitable for mass industrial production and has high economic value.