RESPIRATORY DISEASE-RELATED GENE SPECIFIC siRNA, DOUBLE-HELICAL OLIGO RNA STRUCTURE CONTAINING SUCH siRNA, AND COMPOSITION CONTAINING THE SAME FOR PREVENTING OR TREATING RESPIRATORY DISEASES

摘要

PROBLEM TO BE SOLVED: To provide a gene specific siRNA related with respiratory diseases, a highly efficient double-helical oligo RNA structure containing the same, and a composition containing the same for preventing or treating respiratory diseases.SOLUTION: There is provided a double-helical oligo RNA structure represented by the structural formula 1 defined by A-X-R-Y-B, where A is a hydrophilic material; B is a hydrophobic material; X and Y are each independently a simple covalent bond or a linker-mediated covalent bond; and R is CTGF-specific siRNA.SELECTED DRAWING: Figure 1