RESPIRATORY DISEASE-RELATED GENE SPECIFIC siRNA, DOUBLE-HELICAL OLIGO RNA STRUCTURE CONTAINING SUCH siRNA, COMPOSITION CONTAINING THE SAME FOR PREVENTING OR TREATING RESPIRATORY DISEASE

摘要

To provide gene specific siRNAs related to respiratory diseases, especially to idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease (COPD), and to provide highly efficient double-helical oligo RNA structures containing the same.SOLUTION: Provided is a high efficiency double helix oligo RNA structure, which has a structure in a form joined with a hydrophilic substance and a hydrophobic substance to both ends of a double helix RNA (siRNA) using a simple covalent bond or a linker-mediated covalent bond, in order to be efficiently transmitted into cells, and which can be converted in a nanoparticle form by hydrophobic interaction of double-helix oligo RNA structures in aqueous solution, the siRNA contained in the double helix oligo RNA structure being a respiratory disease, in particular idiopathic pulmonary fibrosis and COPD-related genes CTGF, Cyr61 or Plekho1 specific siRNA.SELECTED DRAWING: Figure 1