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Metal complex having a bisphosphonate or pyrophosphate useful as an imaging agent

机译:具有双膦酸盐或焦磷酸盐的金属配合物,可用作显像剂

摘要

As used herein, a compound of the formula Y-X-Z wherein X is Fe (III) or Mn (II), Y and Z are each independently pyrophosphate and a bisphosphonate (eg 1-hydroxybisphosphonate) (MRI) contrast agent comprising a compound having a structure represented by the following formula (I) or a pharmaceutically acceptable hydrate and / or a salt thereof. Methods of using MRI contrast agents are also provided.
机译:如本文所用,其中X为Fe(III)或Mn(II),Y和Z各自独立地为焦磷酸盐的式YXZ化合物和双膦酸酯(例如1-羟基双膦酸酯)(MRI)造影剂,其包含具有结构由下式(I)表示的化合物或其药学上可接受的水合物和/或其盐。还提供了使用MRI造影剂的方法。

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