Genetically modified mesenchymal stem cells expressing α1-antitrypsin (AAT)

摘要

The present invention relates to genetically modified mesenchymal stem cells for use as a medicament in the treatment of medical conditions associated with inflammation and / or undesired immune responses in subjects without α1-antitrypsin (AAT) deficiency Wherein the stem cell comprises (ii) an exogenous nucleic acid comprising a region encoding (i) α1-antitrypsin (AAT) operably linked to a promoter or promoter / enhancer combination. Genetically modified mesenchymal stem cells for use as [Selection figure] None